
Rejuran under the eyes is an injectable treatment containing polynucleotides, usually shortened to PN. Around the eyes, it is mainly considered when the treatment goal is to improve the quality of thin skin, fine lines or a finely creased, crepey texture.
It is not primarily intended to fill a deep tear trough with volume. A hollow under the eyes, pigmentation, visible blood vessels and prominent eye bags can have different causes and require a different assessment.
Rejuran is a brand rather than the name of the treatment category. Within the range, Rejuran I is positioned for thinner, delicate skin, including fine lines around the eye area. Rejuran products contain salmon-derived polynucleotides.
Whether treatment is relevant therefore depends more on why the under-eye area looks the way it does than on the Rejuran name itself.
For the broader treatment context, see the main Rejuran guide.

Rejuran under the eyes is mainly discussed when skin quality is the primary concern. This can include superficial fine lines, thin-looking skin and a finely wrinkled or crepey texture.
A practitioner should first assess which factors are actually contributing to the appearance of the area.
Polynucleotide treatment may be considered where superficial lines or thin, crepey skin are the main concern. The aim is a gradual change in skin quality rather than an obvious increase in volume.
The dedicated Rejuran for fine lines guide covers this overlap in more detail.
Dark circles are not one single condition. Their appearance can be influenced by pigmentation, visible blood vessels, thin skin, anatomical shadowing, swelling or a combination of factors.
This means that describing Rejuran simply as a treatment “for dark circles” is too broad. It may be discussed where skin quality contributes to the appearance, but another approach may be more relevant when the underlying cause is different.
For the concern-specific explanation, see Rejuran for dark circles.
A pronounced tear trough does not result from skin quality alone. Facial anatomy and the distribution of volume beneath the eye can contribute to the shadow.
Rejuran is not primarily designed to replace that missing volume.
Prominent lower-eyelid bags can also have different underlying causes, including swelling and the position of fat beneath the eye. These require assessment before an injectable treatment is chosen.
Rejuran is not a general solution for every under-eye hollow, dark circle or eye bag.
It is not primarily intended to:
replace significant lost volume;
fill a pronounced tear trough;
directly remove skin pigmentation;
directly remove visible blood vessels;
remove prominent structural eye bags;
correct every cause of under-eye shadowing.
If anatomy, volume loss, pigmentation, vascular visibility or swelling is the dominant issue, another treatment direction — or no cosmetic treatment — may be more appropriate.
The distinction is particularly important when comparing Rejuran with a volumising injectable. See Rejuran vs fillers for the dedicated comparison.
Purified salmon-derived polynucleotides are used in cosmetic injectable treatments around the eyes. Research into PN injections as a treatment category has reported possible improvements in aspects of fine lines and skin quality, but the evidence remains limited.
Importantly, research into one PN product cannot automatically be used as proof that Rejuran will produce the same result.
Rejuran under the eyes is intended to produce gradual changes in skin quality, rather than the immediate volume effect associated with a traditional filler.
Where fine lines or a thin, finely creased under-eye texture are the main concern, treatment may result in a visible improvement. How much difference is noticeable and when it appears varies between individuals.
The outcome can depend on:
the starting condition of the skin;
the exact under-eye concern;
the Rejuran product used;
the treatment plan;
individual response.
If deep hollowing, pigmentation or prominent eye bags are mainly responsible for the appearance, Rejuran may produce little visible change in that specific concern.
A practitioner should explain what they expect the treatment to change and what is likely to remain before treatment begins.




Local reactions can occur after injections around the eyes. These may include redness, swelling, tenderness, small injection points, temporary raised areas or bruising.
How noticeable these are and how long they remain visible can vary according to the person, product and injection technique.
Follow the aftercare instructions provided for the specific product and treatment.
Do not rub or massage the treated area unless your practitioner specifically advises you to do so. When planning treatment, allow for the possibility that swelling, injection marks or bruising may remain temporarily visible.
For the full recovery guidance, see Rejuran recovery.
Contact the treating clinic if symptoms become unexpectedly worse, differ significantly from what was explained during consultation or do not improve as expected.
Acute changes in vision, severe or rapidly increasing pain or swelling, breathing difficulty or another serious unexpected symptom require prompt medical assessment.
Tell the practitioner about relevant health conditions, medication, allergies, previous injectable treatments and current skin problems around the eyes.
Rejuran products use salmon-derived polynucleotides, so disclose a known fish allergy. Pregnancy or breastfeeding should also be discussed before treatment.
Whether treatment should be delayed or avoided depends on your circumstances and the official information for the exact product being used.
For the wider safety discussion, see Rejuran side effects.
The price of Rejuran under-eye treatment can vary according to the clinic, product used, proposed treatment plan and number of sessions.
Rather than comparing only a single advertised starting price, check what the complete proposed treatment course includes.
Useful questions include:
Which Rejuran formulation will be used?
How much product is proposed?
How many sessions are being recommended?
Are consultation and review appointments included?
What follow-up is available if you have concerns?
For current price information and the factors behind price differences, see Rejuran costs.
For an injectable treatment around the eyes, compare more than price. The consultation should establish who will perform the treatment, what product will be used, what is causing the concern and why Rejuran is being proposed.
Useful points to compare include:
who will actually perform the injections;
the practitioner's relevant professional background;
professional registration where relevant to their role;
experience with injectable treatments around the eyes;
experience using Rejuran or comparable PN treatments;
which Rejuran formulation will be used;
why that product is being proposed;
whether alternatives or no treatment are discussed;
how realistic results and limitations are explained;
how the clinic manages follow-up and unexpected reactions;
the cost of the complete proposed treatment plan.
Professional registration can provide useful information about a practitioner's professional status where applicable, but registration alone does not demonstrate extensive experience with Rejuran or the under-eye area.
For a more detailed comparison checklist, read how to choose a Rejuran practitioner.
You can then decide whether you want to request a consultation. Choosing not to proceed remains a valid option.

Rejuran under the eyes is an injectable polynucleotide treatment used with the aim of improving skin quality and fine lines around the delicate eye area. It is not primarily intended to fill a deep tear trough with volume.
Salmon-derived polynucleotides are used in cosmetic injectables around the eyes, and research into PN treatments has reported possible improvements in aspects of fine lines and skin quality. The evidence remains limited, however, and not every study has used Rejuran.
Rejuran I is a formulation within the Rejuran range positioned for thin, delicate skin, including the area around the eyes. The clinic should explain exactly which product it proposes to use and why.
It depends on what is causing the darkness. Thin skin, pigmentation, visible blood vessels, anatomical shadowing, volume loss and swelling can all contribute, so Rejuran is not automatically appropriate for every dark circle.
No. Rejuran primarily targets skin quality, while a dermal filler adds volume when this is appropriately indicated. The two treatments therefore have different treatment goals.
Rejuran is not primarily intended to add enough volume to correct a pronounced tear-trough hollow. If structural hollowing is the main concern, it requires a separate assessment.
It should not be expected to remove prominent eye bags. Their appearance can be related to anatomy, fat compartments or swelling rather than simply skin quality.
Temporary injection-site reactions can include small raised areas, redness, swelling, tenderness, injection marks or bruising. Contact the clinic if symptoms become unexpectedly severe or worsen rather than improve.
There is no fixed number that applies to everyone. The proposed treatment plan depends on the product used, the starting skin condition, the treatment goal and the practitioner's assessment.
PN treatments are intended to produce gradual changes in skin quality rather than immediate filler-like volume. How much difference becomes visible and when it appears varies between individuals.
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